The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment.
نویسندگان
چکیده
The horseshoe crab peptide polyphemusin I possesses high antimicrobial activity, but its mechanism of action is as yet not well defined. Using a biotin-labeled polyphemusin I analogue and confocal fluorescence microscopy, we showed that the peptide accumulates in the cytoplasm of wild-type Escherichia coli within 30 min after addition without causing substantial membrane damage.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 4 شماره
صفحات -
تاریخ انتشار 2006